(R)-2,2,2-Trifluoro-1-phenylethan-1-amine

Name: (R)-2,2,2-Trifluoro-1-phenylethan-1-amine
Brand: ChemScene
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CAS No. 22038-85-3
Cat. No. CS-0005286
Purity≥98%
MDL No.MFCD06738691

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(R)-2,2,2-Trifluoro-1-phenylethan-1-amine|CS-0005286

Structure of 22038-85-3

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General Information

CAS No. 22038-85-3
Cat. No. CS-0005286
Purity ≥98%
MDL No. MFCD06738691
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈F₃N
Molecular Weight None
Synonym(s) (R)-2,2,2-TRIFLUORO-1-PHENYL-ETHYLAMINE
SMILES FC(F)(F)[C@H](N)C1=CC=CC=C1

Description

(R)-2,2,2-Trifluoro-1-phenylethan-1-amine is a chiral amine featuring a trifluoromethyl group adjacent to a phenyl-substituted carbon. This configuration imparts enhanced lipophilicity and metabolic stability, enabling its use in asymmetric synthesis and as a building block for bioactive molecules. The stereogenic center ensures high enantioselectivity in catalytic transformations.

Application

(R)-2,2,2-Trifluoro-1-phenylethan-1-amine serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of fluorinated phenethylamine derivatives with defined stereochemistry. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the primary amine facilitates straightforward functionalization. The compound exhibits good bench stability and is compatible with standard coupling and reduction protocols, making it well-suited for iterative synthetic sequences in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3259
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P280-P301+P330+P331-P302+P352-P304+P340

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Computational Chemistry Data

TPSA 26.02
LogP 2.2487
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(R)-2,2,2-Trifluoro-1-phenylethan-1-amine

CAS No. 22038-85-3

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