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CS-W001157 4
Total: USD 88.00

3-(tert-Butoxycarbonyl)benzeneboronic acid

  • CAS No. 220210-56-0

  • Cat. No. CS-M2539
  • Purity≥98%
  • MDL No.MFCD01630855

*For research and further manufacturing use only, not for direct human use.

3-(tert-Butoxycarbonyl)benzeneboronic acid|CS-M2539

Structure of 220210-56-0

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General Information

  • CAS No. 220210-56-0
  • Cat. No. CS-M2539
  • Purity ≥98%
  • MDL No. MFCD01630855
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅BO₄
  • Molecular Weight 222.05
  • Synonym(s) 3-tert-Butoxycarbonylphenylboronicacid
  • SMILES O=C(OC(C)(C)C)C1=CC(B(O)O)=CC=C1

Description

This boronate moiety features a tert-butyl ester-protected carboxylic acid group, enabling orthogonal functionalization in complex synthesis. The electron-deficient boronic acid integrates efficiently into Suzuki-Miyaura couplings under standard conditions, offering enhanced stability during storage and handling.

Application

3-(tert-Butoxycarbonyl)benzeneboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The tert-butoxycarbonyl (Boc) group provides orthogonal protection for amine functionalities, allowing selective transformations in complex molecule synthesis. Its stability under standard reaction conditions and ease of purification make it ideal for iterative synthetic sequences in medicinal chemistry and materials science.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.76
  • LogP   0.3217
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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