Lot numbers can be found on the outside label of a product:
tert-Butyl morpholine-4-carboxylate
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CAS No. 220199-85-9
- Cat. No. CS-0079698
- Purity≥98%
- MDL No.MFCD11111782
*For research and further manufacturing use only, not for direct human use.
Structure of 220199-85-9
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General Information
- CAS No. 220199-85-9
- Cat. No. CS-0079698
- Purity ≥98%
- MDL No. MFCD11111782
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₁₇NO₃
- Molecular Weight 187.24
- Synonym(s) N-Boc-Morpholine
- SMILES O=C(OC(C)(C)C)N1CCOCC1
Description
tert-Butyl morpholine-4-carboxylate features a sterically hindered tert-butyl ester group that enhances stability and facilitates selective deprotection under mild acidic conditions. This bench-stable reagent integrates readily into synthetic sequences requiring protected nitrogen functionality, particularly in the construction of bioactive heterocycles and peptide mimetics.
Application
tert-Butyl morpholine-4-carboxylate serves as a stable, bench-ready morpholine derivative enabling efficient access to bioactive scaffolds. Its tert-butyl ester group provides excellent functional group tolerance and facilitates straightforward deprotection under mild acidic conditions. The molecule functions as a versatile building block in medicinal chemistry, particularly for constructing morpholine-containing heterocycles via coupling reactions or cyclization strategies.
Synthesis
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Route1
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110-91-8 -
In-stock
24424-99-5 - ~97%
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In-stock
220199-85-9
References
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Sunitha, Sadula; Kanjilal, Sanjit; Reddy, P. Srinivasa; Prasad, Rachapudi B.N. Tetrahedron Letters, 2008 , vol. 49, # 16 p. 2527 - 2532
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Route2
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110-91-8
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In-stock
49761-82-2 - ~89%
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In-stock
220199-85-9
References
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Verma, Sanjeev K.; Ghorpade, Ramarao; Pratap, Ajay; Kaushik Tetrahedron Letters, 2012 , vol. 53, # 19 p. 2373 - 2376
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Route3
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110-91-8
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1538-75-6
- ~93%
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In-stock
220199-85-9
References
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Arifuddin, M.; Lakshmikant, N.; Rajasekar, N.; Shinde, D. B. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2012 , vol. 51, # 8 p. 1168 - 1172,5
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.77
- LogP 1.2537
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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