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(R)-4-Phenyl-2-(quinolin-2-yl)-4,5-dihydrooxazole

  • CAS No. 220108-54-3

  • Cat. No. CS-0096800
  • Purity≥97%
  • MDL No.MFCD29905059

*For research and further manufacturing use only, not for direct human use.

(R)-4-Phenyl-2-(quinolin-2-yl)-4,5-dihydrooxazole|CS-0096800

Structure of 220108-54-3

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General Information

  • CAS No. 220108-54-3
  • Cat. No. CS-0096800
  • Purity ≥97%
  • MDL No. MFCD29905059
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₁₄N₂O
  • Molecular Weight 274.32
  • Synonym(s) 2-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-Quinoline
  • SMILES C1([C@@H]2COC(C3=NC4=CC=CC=C4C=C3)=N2)=CC=CC=C1

Description

(R)-Ph-Quinox features a chiral quinoxaline scaffold with a phenyl substituent, delivering high enantioselectivity in asymmetric synthesis. This bench-stable, moisture-tolerant ligand integrates seamlessly into transition-metal-catalyzed transformations, enabling precise stereocontrol in C–C and C–heteroatom bond formations.

Application

(R)-Ph-Quinox serves as a versatile chiral building block for the synthesis of quinoxaline-based scaffolds, enabling efficient access to biologically relevant heterocycles. Its bench-stable nature and compatibility with standard coupling conditions facilitate straightforward incorporation into complex molecular architectures. Functions effectively in transition-metal-catalyzed cross-couplings and serves as a key intermediate in the construction of medicinally active frameworks.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P233-P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   34.48
  • LogP   3.7529
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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