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CS-W001157 4
Total: USD 88.00

1-Propylpiperazine

  • CAS No. 21867-64-1

  • Cat. No. CS-0124226
  • Purity≥98%
  • MDL No.MFCD00044591

*For research and further manufacturing use only, not for direct human use.

1-Propylpiperazine|CS-0124226

Structure of 21867-64-1

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General Information

  • CAS No. 21867-64-1
  • Cat. No. CS-0124226
  • Purity ≥98%
  • MDL No. MFCD00044591
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆N₂
  • Molecular Weight 128.22
  • Synonym(s) N-Propylpiperazine
  • SMILES CCCN1CCNCC1

Description

1-Propylpiperazine is a versatile nitrogen-rich heterocycle featuring a propyl chain appended to the piperazine ring. This configuration enhances solubility and lipophilicity, enabling efficient integration into medicinal chemistry scaffolds. The molecule exhibits robust stability under standard conditions, facilitating its use in synthetic workflows requiring reliable reactivity.

Application

1-Propylpiperazine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds through standard amine coupling and functionalization reactions. Its propyl-substituted piperazine core exhibits favorable bench stability, solubility, and compatibility with diverse reaction conditions, facilitating efficient synthesis of pharmaceutical intermediates and target molecules.

Synthesis

  • Route1
    • null|null
      110-85-0
    • null|null
      106-94-5
    • ~98%
    • In-stock
      1-Propylpiperazine|CS-0124226
      21867-64-1

    References

    • PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni Patent: WO2012/119941 A1, 2012 ; Location in patent: Page/Page column 129 ; WO 2012/119941 A1
  • Route2
    • null|null
      60206-53-3
    • ~80%
    • In-stock
      1-Propylpiperazine|CS-0124226
      21867-64-1

    References

    • Manetti; Ghelardini; Bartolini; Dei; Galeotti; Gualtieri; Romanelli; Teodori Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4499 - 4507
  • Route3
    • null|null
      110-85-0
    • ~52%
    • In-stock
      1-Propylpiperazine|CS-0124226
      21867-64-1

    References

    • Zlatoidsky; Maliar European Journal of Medicinal Chemistry, 1996 , vol. 31, # 9 p. 669 - 673

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   0.3016
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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