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Structure of 21857-45-4
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5-Methoxyindoline features a planar indoline core with a methoxy group at the 5-position, enhancing electron density and modulating reactivity. This bench-stable heterocycle serves as a key scaffold in medicinal chemistry, enabling efficient incorporation into bioactive molecules through direct functionalization or coupling reactions.
5-Methoxyindoline serves as a versatile building block in medicinal chemistry, enabling the synthesis of indole-based scaffolds with enhanced solubility and metabolic stability. Its ortho-substituted aromatic core facilitates electrophilic substitution and transition-metal-catalyzed coupling reactions. The methoxy group provides moderate electron donation, improving reactivity in C–H functionalization and Pd-catalyzed cross-coupling protocols. Bench-stable and easily purified, it functions reliably in multi-step syntheses of kinase inhibitors and CNS-targeted compounds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: