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Structure of 216976-30-6
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3-Fluoro-5-methylbenzonitrile features a strategically positioned nitrile group flanked by fluorine and methyl substituents, enabling precise tuning of electronic properties. This electron-deficient aromatic scaffold integrates readily into pharmaceutical intermediates and agrochemical building blocks, offering enhanced metabolic stability and controlled reactivity under standard conditions.
3-Fluoro-5-methylbenzonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its ortho-fluorine and meta-methyl substituents provide distinct electronic and steric profiles that enhance regioselectivity in electrophilic substitution and transition-metal-catalyzed coupling reactions. The nitrile group offers a handle for downstream transformations including hydrolysis to carboxylic acids or reductive conversion to aldehydes. Bench-stable and readily purified by distillation or column chromatography, it functions effectively in standard synthetic workflows.
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GHS No : GHS06
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Signal Word : Danger
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UN#: 3439
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H302-H311-H312-H315-H319-H332-H335
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Precautionary Statements : P261-P262-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P332-P361+P364-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: