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CS-W001157 4
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(R)-1-(tert-Butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid

  • CAS No. 2166008-44-0

  • Cat. No. CS-0476417
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R)-1-(tert-Butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid|CS-0476417

Structure of 2166008-44-0

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General Information

  • CAS No. 2166008-44-0
  • Cat. No. CS-0476417
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₇F₂NO₄
  • Molecular Weight 265.25
  • Synonym(s) None
  • SMILES CC(C)(C)OC(=O)N1CCC(F)(F)C[C@@H]1C(O)=O

Description

This chiral piperidine derivative features a bench-stable tert-butyl carbamate protecting group and two fluorine atoms at the 4-position, enhancing metabolic stability and modulating electronic properties. The carboxylic acid functionality enables direct coupling in peptide synthesis or further derivatization.

Application

(R)-1-(tert-Butoxycarbonyl)-4,4-difluoropiperidine-2-carboxylic acid serves as a versatile chiral building block for the synthesis of fluorinated piperidine-containing scaffolds. The difluoropiperidine core imparts enhanced metabolic stability and modulates lipophilicity, while the Boc group enables straightforward deprotection and further functionalization. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient incorporation into peptide-like compounds and medicinal chemistry libraries.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.1058
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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