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CS-W001157 4
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(2S)-1-[(tert-butoxy)carbonyl]-4,4-difluoropiperidine-2-carboxylic acid

  • CAS No. 1221793-42-5

  • Cat. No. CS-0040816
  • Purity≥95%
  • MDL No.MFCD03094869

*For research and further manufacturing use only, not for direct human use.

(2S)-1-[(tert-butoxy)carbonyl]-4,4-difluoropiperidine-2-carboxylic acid|CS-0040816

Structure of 1221793-42-5

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General Information

  • CAS No. 1221793-42-5
  • Cat. No. CS-0040816
  • Purity ≥95%
  • MDL No. MFCD03094869
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₇F₂NO₄
  • Molecular Weight 265.25
  • Synonym(s) (2S)-4,4-Difluoro-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-2-piperi dinecarboxylic acid
  • SMILES O=C(N1[C@H](C(O)=O)CC(F)(F)CC1)OC(C)(C)C

Synthesis

  • Route1
    • 1-(Tert-butyl) 2-methyl (S)-4,4-difluoropiperidine-1,2-dicarboxylate|CS-0493617
      1352342-07-4
    • ~99%
    • In-stock
      (2S)-1-[(tert-butoxy)carbonyl]-4,4-difluoropiperidine-2-carboxylic acid|CS-0040816
      1221793-42-5

    References

    • GILEAD SCIENCES, INC.; CAI, Zhenhong, R.; DU, Zhimin; JI, Mingzhe; JIN, Haolun; KIM, Choung, U.; MISH, Michael, R.; PHILLIPS, Barton, W.; PYUN, Hyung-jung; SHENG, Xiaoning, C.; WU, Qiaoyin; ZONTE, Catalin, Sebastian Patent: WO2011/156610 A2, 2011 ; Location in patent: Page/Page column 102 ;

Safety Information

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Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.1058
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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