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CS-W001157 4
Total: USD 88.00

THP-PEG1-alcohol

  • CAS No. 2162-31-4

  • Cat. No. CS-0096278
  • Purity≥97%
  • MDL No.MFCD00185588

*For research and further manufacturing use only, not for direct human use.

THP-PEG1-alcohol|CS-0096278

Structure of 2162-31-4

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General Information

  • CAS No. 2162-31-4
  • Cat. No. CS-0096278
  • Purity ≥97%
  • MDL No. MFCD00185588
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄O₃
  • Molecular Weight 146.18
  • Synonym(s) None
  • SMILES OCCOC1OCCCC1

Description

THP-PEG1-alcohol is a bench-stable, moisture-tolerant protecting group reagent featuring a labile tetrahydropyranyl ether linkage and a terminal hydroxyl. This structure enables selective protection of alcohols in complex synthetic sequences while facilitating straightforward deprotection under mild acidic conditions. The PEG1 spacer enhances solubility in polar solvents without compromising reactivity.

Application

THP-PEG1-alcohol serves as a versatile, bench-stable protecting group for alcohols in complex molecule synthesis. Its tetrahydropyranyl (THP) moiety enables selective protection under mild acidic conditions, while the PEG1 spacer provides enhanced solubility and compatibility with polar reaction media. This combination facilitates efficient purification and orthogonal deprotection sequences in multi-step synthetic campaigns.

Synthesis

  • Route1
    • null|null
      110-87-2
    • In-stock
      Ethylene glycol,98%|CS-0015059
      107-21-1
    • ~90%
    • In-stock
      THP-PEG1-alcohol|CS-0096278
      2162-31-4

    References

    • Eshghi, Hossein; Shafieyoon, Parvaneh Phosphorus, Sulfur and Silicon and the Related Elements, 2004 , vol. 179, # 10 p. 2149 - 2152
  • Route2
    • null|null
      1034098-53-7
    • ~85%
    • In-stock
      THP-PEG1-alcohol|CS-0096278
      2162-31-4

    References

    • Gopinath, Pushparathinam; Nilaya, Surapaneni; Muraleedharan, Kannoth Manheri Organic Letters, 2011 , vol. 13, # 8 p. 1932 - 1935
  • Route3
    • null|null
      110-87-2
    • In-stock
      Ethylene glycol,98%|CS-0015059
      107-21-1
    • ~92%
    • THP-PEG1-THP|CS-0148636
      71033-27-7
    • In-stock
      THP-PEG1-alcohol|CS-0096278
      2162-31-4

    References

    • Synthetic Communications, , vol. 36, # 18 p. 2705 - 2710

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.69
  • LogP   0.5219
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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