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CS-W001157 4
Total: USD 88.00

THP-PEG3-OH

  • CAS No. 60221-37-6

  • Cat. No. CS-0105792
  • Purity≥97%
  • MDL No.MFCD28976687

*For research and further manufacturing use only, not for direct human use.

THP-PEG3-OH|CS-0105792

Structure of 60221-37-6

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General Information

  • CAS No. 60221-37-6
  • Cat. No. CS-0105792
  • Purity ≥97%
  • MDL No. MFCD28976687
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂O₅
  • Molecular Weight 234.29
  • Synonym(s) None
  • SMILES OCCOCCOCCOC1CCCCO1

Description

THP-PEG3-OH is a bench-stable, moisture-tolerant protecting group for hydroxyl functionalities, integrating a tetrahydropyranyl moiety with a triethylene glycol chain. This combination enables selective protection and facile deprotection under mild acidic conditions, streamlining synthesis workflows in carbohydrate and peptide chemistry.

Application

THP-PEG3-OH serves as a versatile, bench-stable protecting group for hydroxyl functionalities, enabling selective deprotection under mild acidic conditions. Its triisopropylsilyl (TIPS) derivative offers enhanced stability in complex synthesis, while the PEG3 spacer provides solubility and reduced aggregation. Widely used in oligonucleotide and peptide conjugation, it facilitates purification and functionalization in multi-step synthetic sequences.

Synthesis

  • Route1
    • null|null
      110-87-2
    • In-stock
      Triethylene glycol|CS-W018156
      112-27-6
    • ~72%
    • In-stock
      THP-PEG3-OH|CS-0105792
      60221-37-6

    References

    • Richard, Antoine; Bourel-Bonnet, Line Chemistry - A European Journal, 2005 , vol. 11, # 24 p. 7315 - 7321

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   57.15
  • LogP   0.5551
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   9

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