2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione

Name: 2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione
Brand: ChemScene
Availability: InStock
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CAS No. 2154356-63-3
Cat. No. CS-0567256
Purity≥96%
MDL No.MFCD32853087

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione|CS-0567256

Structure of 2154356-63-3

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General Information

CAS No. 2154356-63-3
Cat. No. CS-0567256
Purity ≥96%
MDL No. MFCD32853087
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₁₀N₂O₄
Molecular Weight 282.25
Synonym(s) None
SMILES O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(C#C)=C3)=O

Description

This isoindoline-1,3-dione derivative features a reactive ethynyl group enabling efficient coupling in click chemistry applications. The piperidinone moiety imparts stability and enhances solubility, while the electron-deficient core facilitates conjugate addition reactions. Designed for modular synthesis in bioconjugation and medicinal chemistry workflows.

Application

2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione serves as a versatile building block for the construction of complex heterocyclic scaffolds. The terminal alkyne functionality enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC), facilitating rapid access to triazole-linked architectures. Its isoindoline-1,3-dione core exhibits excellent bench stability and compatibility with diverse functional groups, making it well-suited for modular synthesis in medicinal chemistry and materials science applications.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 83.55
LogP 0.2106
H_Acceptors 6
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Life Science PROTAC Ligands for E3 Ligase

Life Science Click Chemistry Reagents Alkyne

Building Blocks Functional Group Alkyne

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Terminal Alkynes

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Chemical Biology Conjugation Chemistry/Click Chemistry Terminal Alkynes

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione

CAS No. 2154356-63-3

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