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(2S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)octahydro-1H-indole-2-carboxylic acid

  • CAS No. 214750-71-7

  • Cat. No. CS-0199367
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)octahydro-1H-indole-2-carboxylic acid|CS-0199367

Structure of 214750-71-7

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General Information

  • CAS No. 214750-71-7
  • Cat. No. CS-0199367
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₂₅NO₄
  • Molecular Weight 391.46
  • Synonym(s) (2S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
  • SMILES C1CCC2C(C1)C[C@@H](C(=O)O)N2C(=O)OCC3C4=CC=CC=C4C5=CC=CC=C53

Description

This fluorenylmethoxycarbonyl-protected indoline derivative features a stable, bench-handled scaffold ideal for peptide synthesis. The C-terminal carboxylic acid group enables direct coupling, while the octahydroindole ring provides enhanced solubility and reduced aggregation in polar solvents.

Application

(2S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)octahydro-1H-indole-2-carboxylic acid serves as a robust chiral building block for peptide synthesis, enabling efficient N-terminal protection of amino acids. The fluorenylmethoxycarbonyl (Fmoc) group provides excellent stability under basic conditions and facilitates straightforward removal via mild base treatment. Its octahydroindole scaffold offers defined stereochemistry and functional group compatibility, supporting diverse coupling reactions in solid-phase and solution-phase workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   4.6532
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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