Fmoc-Oic-OH

Name: Fmoc-Oic-OH
Brand: ChemScene
Availability: InStock
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CAS No. 130309-37-4
Cat. No. CS-W022729
Purity≥98%
MDL No.MFCD09750487

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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General Information

CAS No. 130309-37-4
Cat. No. CS-W022729
Purity ≥98%
MDL No. MFCD09750487
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₅NO₄
Molecular Weight 391.47
Synonym(s) None
SMILES O=C(O)[C@H]1N([C@]2(CCCC[C@]2(C1)[H])[H])C(OCC3C4=C(C=CC=C4)C5=C3C=CC=C5)=O

Description

Fmoc-Oic-OH is a protected amino acid derivative featuring a fluorinated indole side chain, designed for efficient incorporation into peptide sequences. This scaffold enhances backbone stability and provides unique steric and electronic profiles beneficial in bioactive peptide design. The Fmoc group enables straightforward solid-phase synthesis under standard conditions.

Application

Fmoc-Oic-OH serves as a valuable building block in peptide synthesis, enabling the incorporation of ortho-iodophenylalanine residues with high fidelity. The Fmoc group provides excellent protection for the amine, allowing for efficient stepwise elongation under standard coupling conditions. The ortho-iodinated aromatic side chain offers a versatile handle for subsequent palladium-catalyzed transformations, facilitating site-specific modifications in complex peptide architectures. Its bench stability and compatibility with common purification methods make it a practical choice for synthetic applications requiring functionalized amino acid units.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 66.84
LogP 4.6532
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Bioactive Molecules Peptides

Building Blocks Functional Group Fmoc

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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Fmoc-Oic-OH

CAS No. 130309-37-4

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