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CS-W001157 4
Total: USD 88.00

2-(4-Bromopyrazol-1-yl)ethanol

  • CAS No. 214614-81-0

  • Cat. No. CS-D1257
  • Purity≥95%
  • MDL No.MFCD06804929

*For research and further manufacturing use only, not for direct human use.

2-(4-Bromopyrazol-1-yl)ethanol|CS-D1257

Structure of 214614-81-0

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General Information

  • CAS No. 214614-81-0
  • Cat. No. CS-D1257
  • Purity ≥95%
  • MDL No. MFCD06804929
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇BrN₂O
  • Molecular Weight 191.03
  • Synonym(s) 2-(4-bromo-1H-pyrazol-1-yl)ethanol
  • SMILES BrC1=CN(CCO)N=C1

Description

2-(4-Bromopyrazol-1-yl)ethanol features a brominated pyrazole ring linked to a flexible ethanolic side chain, enabling seamless integration into diverse synthetic scaffolds. This bench-stable, moisture-tolerant reagent facilitates efficient coupling reactions and serves as a key intermediate in medicinal chemistry, particularly for constructing bioactive heterocycles with enhanced solubility and metabolic stability.

Application

2-(4-Bromopyrazol-1-yl)ethanol serves as a versatile building block for the synthesis of pyrazole-based pharmaceutical intermediates and functionalized heterocycles. Its bromine atom enables palladium-catalyzed cross-coupling reactions, while the terminal hydroxyl group facilitates derivatization via etherification or esterification. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   0.6379
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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