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CS-W001157 4
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2-(4-Methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 214360-63-1

  • Cat. No. CS-0088571
  • Purity≥97%
  • MDL No.MFCD22414466

*For research and further manufacturing use only, not for direct human use.

2-(4-Methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0088571

Structure of 214360-63-1

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General Information

  • CAS No. 214360-63-1
  • Cat. No. CS-0088571
  • Purity ≥97%
  • MDL No. MFCD22414466
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₁BO₃
  • Molecular Weight 248.13
  • Synonym(s) None
  • SMILES CC(O1)(C)C(C)(C)OB1C2=CC(C)=C(OC)C=C2

Description

This boronate ester features a methoxy-substituted aryl group enabling efficient cross-coupling in palladium-catalyzed reactions. The tetramethylcyclopentadienone core provides exceptional stability and moisture tolerance, simplifying handling under standard conditions.

Application

2-(4-Methoxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. Its ortho-methyl and para-methoxy substituents provide predictable regiochemistry and enhanced electronic tuning, enabling efficient C–C bond formation under mild conditions. The tetramethyl-substituted dioxaborolane core ensures excellent shelf stability, low hydrolytic sensitivity, and straightforward purification, making it ideal for iterative synthesis of complex aromatic scaffolds in medicinal chemistry and materials science workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

  • TPSA   27.69
  • LogP   2.30282
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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