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CS-W001157 4
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5-Bromopyrimidin-2-ol

  • CAS No. 214290-49-0

  • Cat. No. CS-0166880
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromopyrimidin-2-ol|CS-0166880

Structure of 214290-49-0

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General Information

  • CAS No. 214290-49-0
  • Cat. No. CS-0166880
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃BrN₂O
  • Molecular Weight 174.98
  • Synonym(s) 2(1H)-PYRIMIDINONE,5-BROMO
  • SMILES OC1=NC=C(Br)C=N1

Description

5-Bromopyrimidin-2-ol features a bromine substituent at the 5-position and a hydroxyl group at the 2-position on a pyrimidine core. This combination imparts enhanced reactivity for nucleophilic substitution and facilitates direct functionalization in heterocyclic synthesis. The compound serves as a key intermediate in medicinal chemistry and agrochemical development, offering reliable access to substituted pyrimidines under mild conditions.

Application

5-Bromopyrimidin-2-ol serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient access to pyrimidine-based scaffolds. Its bromine substituent facilitates palladium-catalyzed cross-coupling reactions, while the hydroxyl group offers potential for derivatization or protection. The compound exhibits good bench stability and is compatible with standard reaction conditions, making it a practical choice for constructing functionalized heterocycles in drug discovery and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   0.9447
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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