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CS-W001157 4
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(R)-5-Methylpyrrolidin-2-one

  • CAS No. 21395-93-7

  • Cat. No. CS-0046592
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R)-5-Methylpyrrolidin-2-one|CS-0046592

Structure of 21395-93-7

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General Information

  • CAS No. 21395-93-7
  • Cat. No. CS-0046592
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO
  • Molecular Weight 99.13
  • Synonym(s) (5R)-5-Methyl-2-pyrrolidinone
  • SMILES O=C1CC[C@@H](C)N1

Description

(R)-5-Methylpyrrolidin-2-one is a chiral lactam featuring a stereodefined methyl group at the 5-position, enhancing its conformational rigidity. This bench-stable heterocycle serves as a privileged scaffold in medicinal chemistry, integrating readily into bioactive molecules through selective functionalization at the carbonyl and C5 sites.

Application

(R)-5-Methylpyrrolidin-2-one serves as a valuable chiral building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its inherent stability and well-defined stereochemistry facilitate direct incorporation into complex scaffolds via nucleophilic substitution or reductive amination. The molecule exhibits excellent functional group tolerance and simplifies purification due to its crystalline nature, making it ideal for scalable synthesis and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   0.2849
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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