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CS-W001157 4
Total: USD 88.00

5,5-Dimethylpyrrolidin-2-one

  • CAS No. 5165-28-6

  • Cat. No. CS-W022267
  • Purity≥95%
  • MDL No.MFCD00128876

*For research and further manufacturing use only, not for direct human use.

5,5-Dimethylpyrrolidin-2-one|CS-W022267

Structure of 5165-28-6

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General Information

  • CAS No. 5165-28-6
  • Cat. No. CS-W022267
  • Purity ≥95%
  • MDL No. MFCD00128876
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO
  • Molecular Weight 113.16
  • Synonym(s) 5,5-DiMethylpyrrolidine-2-one
  • SMILES CC1(C)CCC(=O)N1

Description

5,5-Dimethylpyrrolidin-2-one is a sterically hindered lactam featuring a stable five-membered ring with a ketone functionality. This bench-stable compound serves as a versatile scaffold in medicinal chemistry, offering enhanced metabolic resistance and improved solubility profiles in polar solvents. Its rigid structure facilitates precise molecular positioning in drug design.

Application

5,5-Dimethylpyrrolidin-2-one serves as a stable, bench-friendly building block for heterocyclic synthesis, offering enhanced solubility and functional group tolerance. Its sterically hindered lactam structure facilitates selective transformations, enabling efficient access to complex scaffolds in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      292638-85-8
    • ~80%
    • In-stock
      5,5-Dimethylpyrrolidin-2-one|CS-W022267
      5165-28-6

    References

    • BASF Aktiengesellschaft Patent: US4855444 A1, 1989 ;
  • Route2
    • null|null
      79-06-1
    • ~49%
    • In-stock
      5,5-Dimethylpyrrolidin-2-one|CS-W022267
      5165-28-6

    References

    • BASF Aktiengesellschaft Patent: US4855444 A1, 1989 ;
  • Route3
    • null|null
      70265-05-3
    • ~97%
    • In-stock
      5,5-Dimethylpyrrolidin-2-one|CS-W022267
      5165-28-6

    References

    • Marson, Charles M.; Fallah, Asad Tetrahedron Letters, 1994 , vol. 35, # 2 p. 293 - 296

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   0.675
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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