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Structure of 2134618-53-2
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7-Bromo-2,4-dichloro-8-fluoro-6-(trifluoromethyl)quinazoline is a highly functionalized quinazoline scaffold featuring halogen substituents at key positions. This electron-deficient core integrates bromine, chlorine, fluorine, and a trifluoromethyl group, enabling diverse cross-coupling transformations. The molecule exhibits enhanced metabolic stability and favorable binding affinity in kinase-targeted drug discovery.
7-Bromo-2,4-dichloro-8-fluoro-6-(trifluoromethyl)quinazoline serves as a versatile building block for the synthesis of kinase inhibitors and other bioactive heterocycles. Its electron-deficient quinazoline core enables efficient palladium-catalyzed cross-coupling reactions, while the orthogonal halogenation pattern supports sequential functionalization. The trifluoromethyl and fluoro substituents enhance metabolic stability and modulate electronic properties, making it well-suited for medicinal chemistry applications requiring precise tuning of lipophilicity and binding affinity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: