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CS-W001157 4
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7-Bromo-2,4,6-trichloro-8-fluoroquinazoline

  • CAS No. 1698028-11-3

  • Cat. No. CS-0050096
  • Molecule weight330.37
  • Purity≥98%
  • MDL No.MFCD29918562

*For research and further manufacturing use only, not for direct human use.

7-Bromo-2,4,6-trichloro-8-fluoroquinazoline|CS-0050096

Structure of 1698028-11-3

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General Information

  • CAS No. 1698028-11-3
  • Cat. No. CS-0050096
  • Purity ≥98%
  • MDL No. MFCD29918562
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈HBrCl₃FN₂
  • Molecular Weight 330.37
  • Synonym(s) 7-BROMO-2,4,6-TRICHLORO-8-FLUOROQUINAZOLINE(WX130484)
  • SMILES FC1=C2N=C(Cl)N=C(Cl)C2=CC(Cl)=C1Br

Description

7-Bromo-2,4,6-trichloro-8-fluoroquinazoline features a highly electron-deficient quinazoline core with strategically positioned halogens enabling diverse cross-coupling transformations. This bench-stable scaffold integrates readily into pharmaceutical intermediates and functional materials, offering predictable reactivity in palladium-catalyzed processes under standard conditions.

Application

7-Bromo-2,4,6-trichloro-8-fluoroquinazoline serves as a versatile building block for the synthesis of substituted quinazolines via palladium-catalyzed cross-coupling reactions. The strategically positioned halogen atoms enable sequential functionalization at C7 (bromine) and C8 (fluorine), while the electron-deficient core enhances reactivity in nucleophilic substitution processes. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for medicinal chemistry campaigns requiring rapid diversification of quinazoline scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   4.4916
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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