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CS-W001157 4
Total: USD 88.00

1-(4-Fluorophenyl)cyclobutane-1-carboxylic acid

  • CAS No. 151157-46-9

  • Cat. No. CS-0132702
  • Purity≥97%
  • MDL No.MFCD08442159

*For research and further manufacturing use only, not for direct human use.

1-(4-Fluorophenyl)cyclobutane-1-carboxylic acid|CS-0132702

Structure of 151157-46-9

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General Information

  • CAS No. 151157-46-9
  • Cat. No. CS-0132702
  • Purity ≥97%
  • MDL No. MFCD08442159
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁FO₂
  • Molecular Weight 194.20
  • Synonym(s) 1-(4-Fluorophenyl)cyclobutanecarboxylic acid
  • SMILES O=C(C1(C2=CC=C(F)C=C2)CCC1)O

Description

This cyclobutane carboxylic acid features a para-fluorophenyl substituent, delivering enhanced electron-withdrawing character and improved metabolic stability. The rigid cyclobutane scaffold provides conformational control, while the carboxylic acid functionality enables direct derivatization or salt formation. Ideal for medicinal chemistry campaigns requiring lipophilic, bioactive scaffolds with defined stereochemistry.

Application

1-(4-Fluorophenyl)cyclobutane-1-carboxylic acid serves as a valuable building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard functional group transformations. Its cyclobutane core provides conformational rigidity, while the pendant 4-fluorophenyl group enhances metabolic stability and modulates lipophilicity. The carboxylic acid functionality facilitates direct coupling reactions or derivatization, offering versatility in peptide and small-molecule synthesis. Bench-stable and compatible with common purification methods, it supports efficient route development for target-oriented synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.332
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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