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CS-W001157 4
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Methyldiphenylphosphine oxide

  • CAS No. 2129-89-7

  • Cat. No. CS-W014851
  • Purity≥98%
  • MDL No.MFCD00002081

*For research and further manufacturing use only, not for direct human use.

Methyldiphenylphosphine oxide|CS-W014851

Structure of 2129-89-7

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General Information

  • CAS No. 2129-89-7
  • Cat. No. CS-W014851
  • Purity ≥98%
  • MDL No. MFCD00002081
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₃OP
  • Molecular Weight 216.22
  • Synonym(s) methyl(diphenyl)phosphane oxide
  • SMILES CP(C1=CC=CC=C1)(C2=CC=CC=C2)=O

Description

Methyldiphenylphosphine oxide features a phosphine oxide functionality flanked by two phenyl rings and a methyl group, delivering enhanced solubility in organic media while maintaining thermal stability. This structure supports its role as a robust ligand in transition metal catalysis and facilitates efficient coordination in palladium- and nickel-catalyzed cross-coupling reactions under standard conditions.

Synthesis

  • Route1

    References

    • Renard, Pierre-Yves; Vayron, Philippe; Leclerc, Eric; Valleix, Alain; Mioskowski, Charles Angewandte Chemie - International Edition, 2003 , vol. 42, # 21 p. 2389 - 2392
  • Route2
    • In-stock
      Diphenylphosphine oxide|CS-W007660
      4559-70-0
    • null|null
      74-88-4
    • ~94%
    • In-stock
      Methyldiphenylphosphine oxide|CS-W014851
      2129-89-7

    References

    • Tsvetkov, E. N.; Bondarenko, N. A.; Malakhova, I. G.; Kabachnik, M. I. J. Gen. Chem. USSR (Engl. Transl.), 1985 , vol. 55, # 1 p. 11 - 26,8 - 22
  • Route3

    References

    • Bloomfield, Aaron J.; Herzon, Seth B. Organic Letters, 2012 , vol. 14, # 17 p. 4370 - 4373

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.6303
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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