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CS-W001157 4
Total: USD 88.00

N-Mal-N-bis(PEG4-NH-Boc)

  • CAS No. 2128735-27-1

  • Cat. No. CS-0115079
  • Molecule weight806.94
  • Purity≥96%
  • MDL No.MFCD31536761

*For research and further manufacturing use only, not for direct human use.

N-Mal-N-bis(PEG4-NH-Boc)|CS-0115079

Structure of 2128735-27-1

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General Information

  • CAS No. 2128735-27-1
  • Cat. No. CS-0115079
  • Purity ≥96%
  • MDL No. MFCD31536761
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₇H₆₆N₄O₁₅
  • Molecular Weight 806.94
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)NCCOCCOCCOCCOCCN(C(CCN1C(C=CC1=O)=O)=O)CCOCCOCCOCCOCCNC(OC(C)(C)C)=O

Description

N-Mal-N-bis(PEG4-NH-Boc) features a bis-PEGylated maleimide moiety with dual PEG4-NH-Boc protecting groups, enabling site-specific conjugation in aqueous environments. This derivative combines enhanced solubility and stability with controlled reactivity, facilitating efficient bioconjugation workflows under physiological conditions.

Application

N-Mal-N-bis(PEG4-NH-Boc) serves as a versatile bifunctional linker for conjugation chemistry, combining maleimide reactivity with PEGylated amine protection. The maleimide group enables efficient, selective Michael addition with thiols under physiological conditions, while the PEG4-protected amines offer enhanced solubility and stability. This compound facilitates site-specific bioconjugation in antibody-drug conjugate (ADC) development and peptide-protein labeling, enabling straightforward purification and controlled release via deprotection.

Safety Information

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GHS Pictogram : N/A
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Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   208.19
  • LogP   1.3123
  • H_Acceptors   15
  • H_Donors   2
  • Rotatable_Bonds   33

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