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CS-W001157 4
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2-(2,5-Dihydrofuran-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 212127-80-5

  • Cat. No. CS-0052307
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(2,5-Dihydrofuran-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0052307

Structure of 212127-80-5

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General Information

  • CAS No. 212127-80-5
  • Cat. No. CS-0052307
  • Purity ≥96%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₇BO₃
  • Molecular Weight 196.05
  • Synonym(s) 2,5-Dihydrofuran-3-boronic Acid Pinacol Ester
  • SMILES CC1(C)OB(OC1(C)C)C1=CCOC1

Description

This boronate ester features a 2,5-dihydrofuran-3-yl group integrated via a stable dioxaborolane scaffold. The structure combines enhanced stability with efficient coupling performance in Suzuki-Miyaura reactions. Ideal for constructing complex heterocyclic architectures under mild conditions.

Application

2-(2,5-Dihydrofuran-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. The 2,5-dihydrofuran moiety provides a versatile handle for late-stage functionalization in heterocyclic synthesis, with excellent functional group tolerance and predictable reactivity. Its tetramethyl-substituted dioxaborolane ring ensures high chemical stability and ease of purification, making it ideal for iterative coupling strategies in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   27.69
  • LogP   1.5744
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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