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Structure of 21168-41-2
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Ethyl 4,6-dichloroquinoline-3-carboxylate features a rigid quinoline core with strategically positioned chloro substituents at the 4- and 6-positions, enhancing electron deficiency for electrophilic substitution. The ester functionality enables facile derivatization in transition metal-catalyzed coupling reactions. This bench-stable reagent serves as a key intermediate in synthesizing bioactive quinoline-based pharmaceuticals and functional materials.
Ethyl 4,6-dichloroquinoline-3-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted quinoline scaffolds. The dichloro substitution pattern facilitates regioselective palladium-catalyzed cross-coupling reactions, while the ester functionality supports subsequent transformations including hydrolysis and amidation. Bench-stable and readily purified by column chromatography, it functions as a key intermediate in the construction of bioactive molecules and pharmaceutical candidates requiring functionalized quinoline cores.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: