Fmoc-Phe(3-Me)-OH

Name: Fmoc-Phe(3-Me)-OH
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CAS No. 211637-74-0
Cat. No. CS-W013868
Purity≥96%
MDL No.MFCD01863050

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 211637-74-0
Cat. No. CS-W013868
Purity ≥96%
MDL No. MFCD01863050
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₃NO₄
Molecular Weight 401.45
Synonym(s) None
SMILES O=C(O)[C@H](CC1=CC=CC(C)=C1)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

Description

Fmoc-Phe(3-Me)-OH features a phenylalanine residue with a 3-methyl substitution, enhancing hydrophobicity and steric bulk. This modification improves peptide stability and membrane permeability in synthetic sequences. The Fmoc group enables efficient solid-phase peptide synthesis under standard conditions.

Application

Fmoc-Phe(3-Me)-OH serves as a valuable building block in peptide synthesis, offering enhanced hydrophobicity and metabolic stability due to the 3-methyl substitution on the phenyl ring. The Fmoc group enables efficient base-mediated deprotection, while the side chain’s methyl group improves resistance to oxidative degradation. This derivative facilitates the incorporation of sterically hindered, lipophilic residues into therapeutic peptides with improved pharmacokinetic profiles.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 75.63
LogP 4.52942
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Building Blocks Functional Group Fmoc

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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Fmoc-Phe(3-Me)-OH

CAS No. 211637-74-0

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