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CS-W001157 4
Total: USD 88.00

1-(2,2,2-trifluoroacetyl)indoline-5-sulfonyl chloride

  • CAS No. 210691-38-6

  • Cat. No. CS-0003912
  • Purity≥98%
  • MDL No.MFCD09261241
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(2,2,2-trifluoroacetyl)indoline-5-sulfonyl chloride|CS-0003912

Structure of 210691-38-6

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Description

This sulfonyl chloride features a trifluoromethylated acetyl group fused to an indoline scaffold, delivering enhanced reactivity and stability. The electron-deficient sulfonyl chloride moiety enables efficient coupling in amide bond formation, while the aromatic indoline core provides structural rigidity. Ideal for constructing bioactive molecules in medicinal chemistry workflows under standard conditions.

Application

1-(2,2,2-Trifluoroacetyl)indoline-5-sulfonyl chloride serves as a versatile building block for the synthesis of sulfonamide-containing heterocycles, enabling efficient construction of indoline-based scaffolds with enhanced metabolic stability. The trifluoroacetyl group provides orthogonal reactivity, while the sulfonyl chloride moiety facilitates direct coupling with amines under mild conditions. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for iterative synthesis in medicinal chemistry workflows.

General Information

  • CAS No. 210691-38-6
  • Cat. No. CS-0003912
  • Purity ≥98%
  • MDL No. MFCD09261241
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇ClF₃NO₃S
  • Molecular Weight 313.68
  • Synonym(s) 1-(trifluoroacetyl)indoline-5-sulfonyl chloride
  • SMILES O=S(C1=CC=C(C2=C1)N(CC2)C(C(F)(F)F)=O)(Cl)=O

Computational Chemistry Data

  • TPSA   54.45
  • LogP   2.0655
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group :
Hazard Statements : H290-H314
Precautionary Statements : P234-P260-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501

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