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CS-W001157 4
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(R)-2-(Aminomethyl)-4-methylpentanoic acid

  • CAS No. 210345-89-4

  • Cat. No. CS-0095469
  • Molecule weight145.20
  • Purity≥98%
  • MDL No.MFCD07372885

*For research and further manufacturing use only, not for direct human use.

(R)-2-(Aminomethyl)-4-methylpentanoic acid|CS-0095469

Structure of 210345-89-4

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General Information

  • CAS No. 210345-89-4
  • Cat. No. CS-0095469
  • Purity ≥98%
  • MDL No. MFCD07372885
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅NO₂
  • Molecular Weight 145.20
  • Synonym(s) (R)-2-AMINOMETHYL-4-METHYL-PENTANOIC ACID
  • SMILES CC(C)C[C@H](CN)C(O)=O

Description

(R)-2-(Aminomethyl)-4-methylpentanoic acid is a chiral α-amino acid derivative featuring a branched aliphatic side chain. This structure delivers enhanced metabolic stability and favorable solubility under physiological conditions, enabling efficient incorporation into peptide-based drug candidates and chemical probes.

Application

(R)-2-(Aminomethyl)-4-methylpentanoic acid serves as a valuable chiral building block for synthesizing bioactive molecules, particularly in the development of peptidomimetics and enzyme inhibitors. Its well-defined stereochemistry and compatible functional groups enable efficient coupling reactions and side-chain derivatization. The molecule exhibits excellent bench stability and facilitates straightforward purification, making it suitable for both small-scale medicinal chemistry campaigns and scalable process synthesis.

Synthesis

  • Route1
    • null|null
      210345-88-3
    • ~84%
    • In-stock
      (R)-2-(Aminomethyl)-4-methylpentanoic acid|CS-0095469
      210345-89-4

    References

    • Coffey; Drauz; Roberts; Skidmore; Smith Chemical communications (Cambridge, England), 2001 , # 22 p. 2330 - 2331
  • Route2
    • (R)-2-((((Benzyloxy)carbonyl)amino)methyl)-4-methylpentanoic acid|CS-0186115
      132606-01-0
    • ~91%
    • In-stock
      (R)-2-(Aminomethyl)-4-methylpentanoic acid|CS-0095469
      210345-89-4

    References

    • Reyes-Rangel, Gloria; Jimenez-Gonzalez, Erika; Olivares-Romero, Jose Luis; Juaristi, Eusebio Tetrahedron Asymmetry, 2008 , vol. 19, # 24 p. 2839 - 2849
  • Route3
    • null|null
      501330-99-0
    • ~%
    • In-stock
      (R)-2-(Aminomethyl)-4-methylpentanoic acid|CS-0095469
      210345-89-4

    References

    • Lee, Hee-Seung; Park, Jin-Seong; Kim, Byeong Moon; Gellman, Samuel H. Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1575 - 1578

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   0.692
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   4

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