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CS-W001157 4
Total: USD 88.00

2-Cyano-3-methylpyridine

  • CAS No. 20970-75-6

  • Cat. No. CS-W016588
  • Purity≥98%
  • MDL No.MFCD00190585

*For research and further manufacturing use only, not for direct human use.

2-Cyano-3-methylpyridine|CS-W016588

Structure of 20970-75-6

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General Information

  • CAS No. 20970-75-6
  • Cat. No. CS-W016588
  • Purity ≥98%
  • MDL No. MFCD00190585
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆N₂
  • Molecular Weight 118.14
  • Synonym(s) 3-methylpyridine-2-carbonitrile
  • SMILES C1=CC=NC(=C1C)C#N

Description

2-Cyano-3-methylpyridine features a conjugated cyano group and methyl substituent on a pyridine core, delivering enhanced electron-withdrawing character and improved solubility in organic solvents. This structural configuration enables efficient incorporation into heterocyclic frameworks, serving as a key intermediate in pharmaceutical synthesis and functional materials development under standard bench conditions.

Application

2-Cyano-3-methylpyridine serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized pyridine scaffolds. Its cyano and methyl groups offer orthogonal reactivity for nucleophilic substitution, metal-catalyzed coupling, and oxidation processes. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for medicinal chemistry campaigns and process development workflows.

Synthesis

  • Route1
    • null|null
      1003-73-2
    • ~18%
    • In-stock
      2-Cyano-3-methylpyridine|CS-W016588
      20970-75-6

    References

    • US5219847 A1, ;
  • Route2
    • null|null
      773837-37-9
    • null|null
      1104027-41-9
    • ~%
    • In-stock
      3-Methylisonicotinonitrile|CS-0037320
      7584-05-6
    • In-stock
      2-Cyano-3-methylpyridine|CS-W016588
      20970-75-6

    References

    • WO2009/11904 A1, ; Page/Page column 56-57 ; WO 2009/011904 A1
  • Route3
    • null|null
      1003-73-2
    • null|null
      7677-24-9
    • ~87%
    • In-stock
      5-Methylpicolinonitrile|CS-W003262
      1620-77-5
    • In-stock
      2-Cyano-3-methylpyridine|CS-W016588
      20970-75-6

    References

    • Journal of Organic Chemistry, , vol. 48, # 8 p. 1375 - 1377

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.2617
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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