Fmoc-L-Ala(BCP)-OH

Name: Fmoc-L-Ala(BCP)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 2095488-98-3
Cat. No. CS-0200356
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 2095488-98-3
Cat. No. CS-0200356
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₃H₂₃NO₄
Molecular Weight 377.43
Synonym(s) None
SMILES O=C(OCC1C2=CC=CC=C2C3=CC=CC=C31)N[C@H](C(O)=O)CC45CC(C5)C4

Description

Fmoc-L-Ala(BCP)-OH features a benzylcyclopropyl (BCP) side chain that enhances conformational rigidity and metabolic stability in peptide synthesis. This derivative integrates seamlessly into solid-phase workflows, offering improved solubility and reduced aggregation during chain elongation. The Fmoc group enables efficient deprotection under mild basic conditions.

Application

Fmoc-L-Ala(BCP)-OH serves as a versatile building block for solid-phase peptide synthesis, enabling the incorporation of a bioorthogonal click handle via its benzylcyclopropyl (BCP) side chain. The Fmoc group provides efficient protection for the amine, while the BCP moiety facilitates reliable copper-free ligation under physiological conditions. This derivative offers excellent bench stability, straightforward purification, and compatibility with standard coupling protocols, making it ideal for site-specific conjugation in peptide-drug conjugates and functionalized biomolecules.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

TPSA 75.63
LogP 4.1685
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Life Science Amino Acids and their Derivatives Alanine and derivatives

Building Blocks Functional Group Fmoc

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-L-Ala(BCP)-OH

CAS No. 2095488-98-3

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