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CS-W001157 4
Total: USD 88.00

2-methyl-1,3-thiazole-4-carbaldehyde

  • CAS No. 20949-84-2

  • Cat. No. CS-W003295
  • Purity≥97%
  • MDL No.MFCD06655197

*For research and further manufacturing use only, not for direct human use.

2-methyl-1,3-thiazole-4-carbaldehyde|CS-W003295

Structure of 20949-84-2

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General Information

  • CAS No. 20949-84-2
  • Cat. No. CS-W003295
  • Purity ≥97%
  • MDL No. MFCD06655197
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NOS
  • Molecular Weight 127.16
  • Synonym(s) 4-Formyl-2-methylthiazole
  • SMILES Cc1nc(cs1)C=O

Description

2-Methyl-1,3-thiazole-4-carbaldehyde features a reactive aldehyde group fused to an electron-deficient thiazole ring, enabling direct coupling in heterocyclic synthesis. This bench-stable scaffold integrates readily into medicinal chemistry libraries and serves as a key intermediate for bioactive compound development.

Application

2-Methyl-1,3-thiazole-4-carbaldehyde serves as a versatile building block in heterocyclic synthesis, enabling efficient access to biologically relevant thiazole derivatives. Its aldehyde functionality facilitates standard transformations such as reductive amination, Grignard additions, and Wittig reactions, while the methyl-substituted thiazole ring exhibits good bench stability and functional group tolerance. This compound functions effectively in the construction of pharmaceutical scaffolds and agrochemical intermediates through reliable, well-documented reaction pathways.

Synthesis

  • Route1

    References

    • Zhan, Weiqiang; Jiang, Yi; Brodie, Peggy J.; Kingston, David G. I.; Liotta, Dennis C.; Snyder, James P. Organic Letters, 2008 , vol. 10, # 8 p. 1565 - 1568
  • Route2
    • N-Methoxy-N,2-dimethylthiazole-4-carboxamide|CS-1162127
      721455-02-3
    • ~%
    • In-stock
      2-methyl-1,3-thiazole-4-carbaldehyde|CS-W003295
      20949-84-2

    References

    • WO2004/58702 A2, ; Page 29-30; 23 ; WO 2004/058702 A2
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 44, # 14 p. 2319 - 2332

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.26402
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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