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CS-W001157 4
Total: USD 88.00

6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine

  • CAS No. 2092807-41-3

  • Cat. No. CS-0163384
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine|CS-0163384

Structure of 2092807-41-3

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General Information

  • CAS No. 2092807-41-3
  • Cat. No. CS-0163384
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂Cl₂N₄
  • Molecular Weight 189.00
  • Synonym(s) 6,8-Dichloro[1,2,4]triazolo[1,5-a]pyrazine
  • SMILES ClC1=NC(Cl)=CN2C1=NC=N2

Description

6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine is a heterocyclic scaffold featuring two chlorine substituents at electron-deficient positions, enhancing reactivity in cross-coupling and cyclization processes. This bench-stable, moisture-tolerant core integrates readily into bioactive molecule design, enabling efficient access to nitrogen-rich pharmacophores for medicinal chemistry applications.

Application

6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its dual chloro substituents enable selective nucleophilic substitution reactions, facilitating the installation of diverse aryl, alkyl, and amine functionalities. The rigid, electron-deficient core enhances metabolic stability and supports integration into bioactive scaffolds. Bench-stable and compatible with standard coupling protocols, it functions effectively in multistep synthesis workflows requiring high functional group tolerance.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.08
  • LogP   1.4311
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   0

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