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(S)-Oxetan-2-ylmethanamine

  • CAS No. 2091328-57-1

  • Cat. No. CS-0100100
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-Oxetan-2-ylmethanamine|CS-0100100

Structure of 2091328-57-1

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General Information

  • CAS No. 2091328-57-1
  • Cat. No. CS-0100100
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉NO
  • Molecular Weight 87.12
  • Synonym(s) 2-Oxetanemethanamine, (2S)-
  • SMILES NC[C@H]1OCC1

Description

(S)-Oxetan-2-ylmethanamine features a chiral oxetane ring fused to a primary amine group, offering enhanced metabolic stability and improved solubility in medicinal chemistry applications. This scaffold integrates readily into bioactive molecules, where its strained four-membered ring promotes favorable binding interactions and modulates pharmacokinetic properties through reduced lipophilicity.

Application

(S)-Oxetan-2-ylmethanamine serves as a valuable chiral building block in medicinal chemistry, enabling the construction of oxetane-containing scaffolds with enhanced metabolic stability and improved solubility. Its reactive amine functionality facilitates straightforward derivatization, while the oxetane ring provides conformational rigidity and favorable physicochemical properties. The compound exhibits good bench stability and compatibility with standard synthetic protocols, making it well-suited for use in API development and combinatorial library synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   -0.266
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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