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CS-W001157 4
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5-Bromo-2-methyl-2H-pyrazolo[3,4-c]pyridine

  • CAS No. 2089292-88-4

  • Cat. No. CS-0130159
  • Molecule weight212.05
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-methyl-2H-pyrazolo[3,4-c]pyridine|CS-0130159

Structure of 2089292-88-4

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General Information

  • CAS No. 2089292-88-4
  • Cat. No. CS-0130159
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrN₃
  • Molecular Weight 212.05
  • Synonym(s) 5-bromo-2-methyl-pyrazolo[3,4-c]pyridine
  • SMILES CN1N=C2C=NC(Br)=CC2=C1

Description

5-Bromo-2-methyl-2H-pyrazolo[3,4-c]pyridine is a heterocyclic scaffold featuring a brominated pyrazolopyridine core with a methyl group at the 2-position. This electron-deficient framework integrates readily into cross-coupling reactions and serves as a key building block for bioactive molecules in medicinal chemistry.

Application

5-Bromo-2-methyl-2H-pyrazolo[3,4-c]pyridine serves as a versatile heterocyclic building block for medicinal chemistry and catalytic cross-coupling applications. Its bromo group enables reliable Pd-catalyzed Suzuki, Stille, and Negishi reactions, while the methyl substituent enhances stability and modulates electronic properties. The scaffold exhibits excellent bench stability and facilitates efficient purification, making it well-suited for iterative synthesis of functionalized pyrazolopyridines in drug discovery workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   30.71
  • LogP   1.7308
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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