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CS-W001157 4
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5-Bromo-1-methyl-1H-pyrazolo[3,4-c]pyridine

  • CAS No. 1337880-46-2

  • Cat. No. CS-0101145
  • Molecule weight212.05
  • Purity≥97%
  • MDL No.MFCD22380195

*For research and further manufacturing use only, not for direct human use.

5-Bromo-1-methyl-1H-pyrazolo[3,4-c]pyridine|CS-0101145

Structure of 1337880-46-2

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General Information

  • CAS No. 1337880-46-2
  • Cat. No. CS-0101145
  • Purity ≥97%
  • MDL No. MFCD22380195
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrN₃
  • Molecular Weight 212.05
  • Synonym(s) None
  • SMILES CN1N=CC2=C1C=NC(Br)=C2

Description

5-Bromo-1-methyl-1H-pyrazolo[3,4-c]pyridine is a heterocyclic scaffold featuring a brominated pyrazolopyridine core with a methyl group at the 1-position. This electron-deficient system facilitates transition metal-catalyzed coupling reactions and serves as a key building block in medicinal chemistry for targeted kinase inhibitors and bioactive small molecules.

Application

5-Bromo-1-methyl-1H-pyrazolo[3,4-c]pyridine serves as a versatile heterocyclic building block for medicinal chemistry and catalytic cross-coupling applications. Its bromine substituent enables reliable Pd-catalyzed coupling reactions, while the methyl group enhances solubility and metabolic stability. The fused pyrazolo[3,4-c]pyridine core provides a rigid, planar scaffold with favorable pharmacophoric properties, facilitating incorporation into bioactive molecules. Bench-stable and amenable to standard purification methods, it functions effectively in diverse synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.71
  • LogP   1.7308
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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