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CS-W001157 4
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1-(tert-Butoxycarbonyl)-1H-indole-6-carboxylic acid

  • CAS No. 208772-42-3

  • Cat. No. CS-0227267
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(tert-Butoxycarbonyl)-1H-indole-6-carboxylic acid|CS-0227267

Structure of 208772-42-3

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General Information

  • CAS No. 208772-42-3
  • Cat. No. CS-0227267
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₅NO₄
  • Molecular Weight 261.27
  • Synonym(s) 1-t-butyloxycarbonylindole-6-carboxylic acid
  • SMILES O=C(N1C=CC2=C1C=C(C(O)=O)C=C2)OC(C)(C)C

Description

1-(tert-Butoxycarbonyl)-1H-indole-6-carboxylic acid features a bench-stable, moisture-tolerant Boc-protected indole scaffold with a carboxylic acid handle at the 6-position. This orthogonal functionality enables direct coupling in peptide and macrocycle synthesis, facilitating access to complex heterocyclic architectures under standard conditions.

Application

1-(tert-Butoxycarbonyl)-1H-indole-6-carboxylic acid serves as a versatile building block for the synthesis of indole-based pharmaceuticals and functional materials. The Boc-protected indole scaffold enables selective deprotection and downstream coupling reactions, while the carboxylic acid functionality facilitates amide bond formation and conjugation strategies. Its bench-stable nature and compatibility with standard peptide coupling protocols make it ideal for iterative synthetic workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   68.53
  • LogP   3.1227
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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