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CS-W001157 4
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5-Aminoindolin-2-one

  • CAS No. 20876-36-2

  • Cat. No. CS-W010983
  • Purity≥98%
  • MDL No.MFCD02179603

*For research and further manufacturing use only, not for direct human use.

5-Aminoindolin-2-one|CS-W010983

Structure of 20876-36-2

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General Information

  • CAS No. 20876-36-2
  • Cat. No. CS-W010983
  • Purity ≥98%
  • MDL No. MFCD02179603
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂O
  • Molecular Weight 148.16
  • Synonym(s) 5-Aminooxindole
  • SMILES O=C1NC2=C(C=C(N)C=C2)C1

Description

5-Aminoindolin-2-one is a bench-stable heterocyclic scaffold featuring a fused indoline core with an amino group at the 5-position. This electron-rich system integrates readily into medicinal chemistry campaigns, offering direct access to bioactive analogs through facile derivatization at the amine and carbonyl sites.

Application

5-Aminoindolin-2-one serves as a versatile building block in medicinal chemistry, enabling the synthesis of biologically active heterocycles. Its amino and carbonyl functionalities offer orthogonal reactivity for peptide coupling, cyclization, and transition-metal-catalyzed transformations. The scaffold exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthesis and scale-up in API development.

Synthesis

  • Route1
    • 5-Aminoindoline-2,3-dione|CS-0139774
      42816-53-5
    • ~%
    • In-stock
      5-Aminoindolin-2-one|CS-W010983
      20876-36-2

    References

    • Bioorganic and Medicinal Chemistry, , vol. 21, # 7 p. 1724 - 1734
  • Route2

    References

    • Zhurnal Obshchei Khimii, , vol. 26, p. 2019,2023, 2024; engl. Ausg. S. 2251, 2254, 2255

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   0.7634
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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