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CS-W001157 4
Total: USD 88.00

Z-Ser(Bzl)-OH

  • CAS No. 20806-43-3

  • Cat. No. CS-W011971
  • Purity≥98%
  • MDL No.MFCD00022029

*For research and further manufacturing use only, not for direct human use.

Z-Ser(Bzl)-OH|CS-W011971

Structure of 20806-43-3

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General Information

  • CAS No. 20806-43-3
  • Cat. No. CS-W011971
  • Purity ≥98%
  • MDL No. MFCD00022029
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₁₉NO₅
  • Molecular Weight None
  • Synonym(s) None
  • SMILES O=C([C@H](NC(OCC1=CC=CC=C1)=O)COCC2=CC=CC=C2)O

Description

Z-Ser(Bzl)-OH is a protected serine derivative featuring a benzyl ether group and a carbobenzoxy (Cbz) blocking group. This combination ensures stability during synthesis while enabling selective deprotection. The molecule integrates readily into peptide chains, offering controlled access to serine residues in complex sequences.

Application

Z-Ser(Bzl)-OH serves as a protected serine building block for peptide synthesis, enabling selective incorporation of serine residues with orthogonal protection. The benzyloxycarbonyl (Z) group provides stability and compatibility with standard coupling protocols, while the benzyl (Bzl) ether protects the hydroxyl functionality. This dual protection facilitates efficient sequential assembly in solid-phase and solution-phase peptide synthesis, offering excellent functional group tolerance and ease of purification.

Synthesis

  • Route1

    References

    • Dell'Uomo, Natalina; Giovanni, Maria C. Di; Misiti, Domenico; Zappia, Giovanni; Monache, Giuliano Delle Liebigs Annalen der Chemie, 1994 , # 6 p. 641 - 644
  • Route2
    • In-stock
      H-Ser(Bzl)-OH|CS-W008308
      4726-96-9
    • null|null
      501-53-1
    • ~84%
    • In-stock
      Z-Ser(Bzl)-OH|CS-W011971
      20806-43-3

    References

    • Robertson, Stephanie A.; Ellman, Jonathan A.; Schultz, Peter G. Journal of the American Chemical Society, 1991 , vol. 113, # 7 p. 2722 - 2729
  • Route3
    • null|null
      394210-41-4
    • ~42%
    • In-stock
      Z-Ser(Bzl)-OH|CS-W011971
      20806-43-3

    References

    • Hang; Tian; Tang; Deng Journal of the American Chemical Society, 2001 , vol. 123, # 50 p. 12696 - 12697

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H400
Precautionary Statements : P273

Quality Control

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Computational Chemistry Data

  • TPSA   84.86
  • LogP   2.5828
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   8

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