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CS-W001157 4
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2-Hydroxy-5-methylpyrazine

  • CAS No. 20721-17-9

  • Cat. No. CS-W008795
  • Purity≥95%
  • MDL No.MFCD01693937

*For research and further manufacturing use only, not for direct human use.

2-Hydroxy-5-methylpyrazine|CS-W008795

Structure of 20721-17-9

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General Information

  • CAS No. 20721-17-9
  • Cat. No. CS-W008795
  • Purity ≥95%
  • MDL No. MFCD01693937
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆N₂O
  • Molecular Weight 110.11
  • Synonym(s) None
  • SMILES O=C1C=NC(C)=CN1

Description

5-Methylpyrazin-2(1H)-one is a bench-stable, electron-deficient heterocycle featuring a methyl-substituted pyrazinone core. This compound integrates readily into synthetic sequences requiring nitrogen-rich scaffolds and serves as a key building block in medicinal chemistry for bioactive molecule development.

Application

5-Methylpyrazin-2(1H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to pyrazine-based scaffolds through standard functionalization protocols. Its stability under ambient conditions and compatibility with diverse reaction conditions facilitate straightforward derivatization, including nucleophilic substitution and transition-metal-catalyzed coupling. The compound functions effectively as a key intermediate in the synthesis of bioactive molecules, particularly those requiring nitrogen-rich frameworks with defined electronic properties.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 74, p. 1580,1582 US2520088 , ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   45.75
  • LogP   0.07832
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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