Fmoc-D-Phe(3-Cl)-OH

Name: Fmoc-D-Phe(3-Cl)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 205526-23-4
Cat. No. CS-0151377
Purity≥95%
MDL No.MFCD00672549

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Fmoc-D-Phe(3-Cl)-OH features a fluorophore-masked D-phenylalanine scaffold with a chlorine atom at the meta position of the aromatic ring. This configuration enhances electron-withdrawing character and improves stability during solid-phase peptide synthesis. The protected side chain resists racemization, enabling reliable incorporation into challenging sequences.

Application

Fmoc-D-Phe(3-Cl)-OH serves as a key building block for the synthesis of peptide-based therapeutics and cyclic peptide scaffolds. The 3-chloro substitution on the phenyl ring enhances metabolic stability and modulates lipophilicity, while the Fmoc group enables efficient solid-phase peptide synthesis. This derivative exhibits excellent bench stability, straightforward purification, and compatibility with standard coupling protocols, facilitating reliable incorporation into complex sequences.

General Information

CAS No. 205526-23-4
Cat. No. CS-0151377
Purity ≥95%
MDL No. MFCD00672549
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₀ClNO₄
Molecular Weight 421.87
Synonym(s) Fmoc-D-3-Chlorophenylalanine
SMILES ClC1=CC=CC(C[C@H](C(O)=O)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=C1

Computational Chemistry Data

TPSA 75.63
LogP 4.8744
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P340-P362-P403-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-D-Phe(3-Cl)-OH

CAS No. 205526-23-4

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