Fmoc-D-Phe(3,4-DiF)-OH

Name: Fmoc-D-Phe(3,4-DiF)-OH
Brand: ChemScene
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CAS No. 198545-59-4
Cat. No. CS-0150074
Purity≥97%
MDL No.MFCD00672551

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 198545-59-4

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General Information

CAS No. 198545-59-4
Cat. No. CS-0150074
Purity ≥97%
MDL No. MFCD00672551
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₁₉F₂NO₄
Molecular Weight 423.41
Synonym(s) N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3,4-difluoro-D-phenylalanine
SMILES FC=1C=CC(=CC1F)C[C@H](C(O)=O)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O

Description

Fmoc-D-Phe(3,4-DiF)-OH features a D-phenylalanine scaffold substituted with fluorines at the 3 and 4 positions, enhancing metabolic stability and electron-withdrawing character. This derivative integrates readily into peptide chains under standard coupling conditions, offering improved resistance to enzymatic degradation while maintaining favorable solubility in organic solvents.

Application

Fmoc-D-Phe(3,4-DiF)-OH serves as a robust building block for the synthesis of peptidomimetics and bioactive oligomers. The 3,4-difluorophenyl side chain enhances metabolic stability and modulates electronic properties, while the Fmoc group enables efficient solution-phase and solid-phase peptide coupling. Its bench-stable nature and compatibility with standard deprotection protocols facilitate reliable incorporation into complex sequences.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 75.63
LogP 4.4992
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-D-Phe(3,4-DiF)-OH

CAS No. 198545-59-4

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