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CS-W001157 4
Total: USD 88.00

NH-bis(PEG4-Boc)

  • CAS No. 2055041-41-1

  • Cat. No. CS-0115504
  • Purity≥98%
  • MDL No.MFCD29912666

*For research and further manufacturing use only, not for direct human use.

NH-bis(PEG4-Boc)|CS-0115504

Structure of 2055041-41-1

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General Information

  • CAS No. 2055041-41-1
  • Cat. No. CS-0115504
  • Purity ≥98%
  • MDL No. MFCD29912666
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₀H₅₉NO₁₂
  • Molecular Weight 625.79
  • Synonym(s) None
  • SMILES O=C(CCOCCOCCOCCOCCNCCOCCOCCOCCOCCC(OC(C)(C)C)=O)OC(C)(C)C

Description

NH-bis(PEG4-Boc) features two PEG4-Boc protecting groups flanking a central amine, enabling dual functionalization in peptide and oligonucleotide synthesis. This bifunctional reagent offers enhanced solubility and stability under standard conditions, facilitating efficient coupling reactions while minimizing side processes.

Application

NH-bis(PEG4-Boc) serves as a bifunctional, water-soluble linker for the synthesis of peptide-drug conjugates and macrocyclic architectures. The PEG4 spacer provides enhanced solubility and reduced aggregation, while the two Boc groups enable selective deprotection under mild acidic conditions. This reagent facilitates efficient conjugation workflows and simplifies purification in solid-phase and solution-phase syntheses.

Safety Information

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Computational Chemistry Data

  • TPSA   138.47
  • LogP   2.1724
  • H_Acceptors   13
  • H_Donors   1
  • Rotatable_Bonds   30

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