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Azido-PEG6-NHS ester

  • CAS No. 2055014-64-5

  • Cat. No. CS-0108184
  • Purity≥98%
  • MDL No.MFCD22683276

*For research and further manufacturing use only, not for direct human use.

Azido-PEG6-NHS ester|CS-0108184

Structure of 2055014-64-5

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General Information

  • CAS No. 2055014-64-5
  • Cat. No. CS-0108184
  • Purity ≥98%
  • MDL No. MFCD22683276
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₃₂N₄O₁₀
  • Molecular Weight 476.48
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

Description

Azido-PEG6-NHS ester enables efficient, bioorthogonal conjugation in aqueous environments. This bifunctional reagent combines a moisture-tolerant azide group with a reactive NHS ester, facilitating site-specific labeling of proteins and biomolecules. The six-atom PEG spacer provides enhanced solubility and reduced steric hindrance, improving reaction kinetics and yield.

Application

Azido-PEG6-NHS ester serves as a versatile bifunctional linker for bioconjugation, enabling efficient coupling of azide-containing molecules to primary amines under mild conditions. The PEG6 spacer provides enhanced solubility and reduced steric hindrance, while the NHS ester group ensures high reactivity with amine functionalities. This reagent facilitates site-specific labeling in peptide, protein, and oligonucleotide modifications, offering excellent stability during storage and straightforward purification post-reaction.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   167.82
  • LogP   0.3936
  • H_Acceptors   11
  • H_Donors   0
  • Rotatable_Bonds   22

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