Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

5-Bromo-3-methylisothiazole

  • CAS No. 20493-60-1

  • Cat. No. CS-0136608
  • Purity≥95%
  • MDL No.MFCD01318949

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-methylisothiazole|CS-0136608

Structure of 20493-60-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 20493-60-1
  • Cat. No. CS-0136608
  • Purity ≥95%
  • MDL No. MFCD01318949
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄BrNS
  • Molecular Weight 178.05
  • Synonym(s) 5-BROMO-3-METHYL-ISOTHIAZOLE
  • SMILES CC1=NSC(Br)=C1

Description

5-Bromo-3-methylisothiazole is a heterocyclic compound featuring a bromine atom at the 5-position and a methyl group at the 3-position of the isothiazole ring. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions, serving as a stable building block for bioactive molecule synthesis. Its bench-stable nature facilitates handling under standard conditions.

Application

5-Bromo-3-methylisothiazole serves as a versatile building block for the synthesis of bioactive heterocycles, enabling direct functionalization at the 5-position via palladium-catalyzed cross-coupling. The bromine substituent provides high reactivity in Suzuki, Stille, and Negishi reactions, while the methyl group enhances solubility and modulates electronic properties. Bench-stable and compatible with diverse reaction conditions, it facilitates efficient access to isothiazole-based scaffolds relevant to medicinal chemistry and agrochemical development.

Synthesis

  • Route1
    • null|null
      71134-43-5
    • ~13%
    • In-stock
      5-Bromo-3-methylisothiazole|CS-0136608
      20493-60-1

    References

    • MEMORY PHARMACEUTICALS CORPORATION Patent: WO2009/55437 A2, 2009 ; Location in patent: Page/Page column 66 ;
  • Route2
    • null|null
      71134-43-5
    • In-stock
      Copper sulfate pentahydrate|CS-0433431
      7758-99-8
    • ~27%
    • In-stock
      5-Bromo-3-methylisothiazole|CS-0136608
      20493-60-1

    References

    • Cetusic, Jeannie Rachel; Rieder, Brent Jeffrey Patent: US2004/2545 A1, 2004 ;
  • Route3
    • 5-Amino-3-methylisothiazole|CS-0013032
      24340-76-9
    • ~%
    • In-stock
      5-Bromo-3-methylisothiazole|CS-0136608
      20493-60-1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 1 p. 528 - 530

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.21402
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 5-Bromo-3-methylisothiazole sigma5-Bromo-3-methylisothiazole manufacturer5-Bromo-3-methylisothiazole price5-Bromo-3-methylisothiazole structure5-Bromo-3-methylisothiazole SDSbuy 5-Bromo-3-methylisothiazole5-Bromo-3-methylisothiazole supplier5-Bromo-3-methylisothiazole uses5-Bromo-3-methylisothiazole molecular weightprice of 5-Bromo-3-methylisothiazole5-Bromo-3-methylisothiazole chemical name formula of 5-Bromo-3-methylisothiazole
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label