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CS-W001157 4
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5-(Aminomethyl)-2-fluorophenol hydrochloride

  • CAS No. 2044704-82-5

  • Cat. No. CS-0124019
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(Aminomethyl)-2-fluorophenol hydrochloride|CS-0124019

Structure of 2044704-82-5

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General Information

  • CAS No. 2044704-82-5
  • Cat. No. CS-0124019
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉ClFNO
  • Molecular Weight 177.60
  • Synonym(s) None
  • SMILES OC1=CC(CN)=CC=C1F.[H]Cl

Description

5-(Aminomethyl)-2-fluorophenol hydrochloride features a fluorinated aromatic ring with a strategically positioned aminomethyl group, enabling direct functionalization in medicinal chemistry. The hydrochloride salt enhances solubility and stability under standard conditions, facilitating use in peptide coupling and conjugation workflows.

Application

5-(Aminomethyl)-2-fluorophenol hydrochloride serves as a versatile building block for fluorinated aromatic scaffolds, enabling efficient access to bioactive intermediates. Its ortho-fluoro functionality facilitates directed metalation and nucleophilic substitution, while the pendant primary amine supports facile derivatization via amidation, alkylation, or reductive amination. The hydrochloride salt enhances solubility and stability in aqueous and polar organic media, simplifying handling and purification in multi-step synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.4118
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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