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Structure of 204251-33-2
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Fmoc-D-Glu(OAll)-OH is a protected D-glutamic acid derivative featuring a C-terminal allyl ester and an Nα-Fmoc group. This configuration enables orthogonal deprotection in peptide synthesis, where the Fmoc group is removed under mild base conditions while the allyl ester remains intact. The allyl moiety facilitates subsequent cleavage via palladium-catalyzed reactions, streamlining the introduction of functionalized side chains. The molecule exhibits excellent stability during handling and storage, making it suitable for automated and manual synthesis workflows.
Fmoc-D-Glu(OAll)-OH serves as a key building block in peptide synthesis, enabling the incorporation of D-glutamic acid with orthogonal protection. The Fmoc group allows for mild base-labile deprotection, while the allyl ester (OAll) provides orthogonal cleavage under palladium catalysis, facilitating selective deprotection in complex sequences. Its stability under standard coupling conditions and compatibility with diverse synthetic workflows make it ideal for constructing multifunctional peptides and peptidomimetics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: