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CS-W001157 4
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tert-Butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate

  • CAS No. 203520-03-0

  • Cat. No. CS-0038085
  • Purity≥98%
  • MDL No.MFCD06808758

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate|CS-0038085

Structure of 203520-03-0

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General Information

  • CAS No. 203520-03-0
  • Cat. No. CS-0038085
  • Purity ≥98%
  • MDL No. MFCD06808758
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₇N₃O₃
  • Molecular Weight 297.40
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCN(C(=O)C2CCNCC2)CC1

Description

tert-Butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate is a sterically hindered, bench-stable piperazine derivative featuring a protected amine and a carbonyl-linked piperidine moiety. This scaffold integrates a flexible linker with defined spatial constraints, enabling efficient incorporation into complex molecular architectures. The tert-butyl ester group provides orthogonal protection, facilitating selective deprotection under mild acidic conditions.

Application

tert-Butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate serves as a versatile building block for constructing complex nitrogen-containing scaffolds. The piperazine core enables diverse functionalization, while the tert-butyl ester offers excellent bench stability and straightforward deprotection under mild acidic conditions. Its piperidine carbonyl moiety facilitates amide bond formation and supports incorporation into bioactive molecules via standard coupling protocols.

Synthesis

  • Route1
    • null|null
      203520-02-9
    • ~70%
    • In-stock
      tert-Butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate|CS-0038085
      203520-03-0

    References

    • Brown; Hollinshead; Stokes; Waterson; Clarke; Foubister; Glossop; McTaggart; Mirrlees; Smith; Wood Journal of Medicinal Chemistry, 2000 , vol. 43, # 26 p. 4964 - 4972
  • Route2
    • Piperidine-4-carboxylic acid Avatrombopag Impurity|CS-0377512
      498-94-2
    • ~%
    • In-stock
      tert-Butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate|CS-0038085
      203520-03-0

    References

    • Brown; Hollinshead; Stokes; Waterson; Clarke; Foubister; Glossop; McTaggart; Mirrlees; Smith; Wood Journal of Medicinal Chemistry, 2000 , vol. 43, # 26 p. 4964 - 4972
  • Route3

    References

    • Brown; Hollinshead; Stokes; Waterson; Clarke; Foubister; Glossop; McTaggart; Mirrlees; Smith; Wood Journal of Medicinal Chemistry, 2000 , vol. 43, # 26 p. 4964 - 4972

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   61.88
  • LogP   1.0653
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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