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2-Amino-5-methylpyridin-3-ol

  • CAS No. 20348-17-8

  • Cat. No. CS-0145980
  • Purity≥97%
  • MDL No.MFCD09839244

*For research and further manufacturing use only, not for direct human use.

2-Amino-5-methylpyridin-3-ol|CS-0145980

Structure of 20348-17-8

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General Information

  • CAS No. 20348-17-8
  • Cat. No. CS-0145980
  • Purity ≥97%
  • MDL No. MFCD09839244
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight 124.14
  • Synonym(s) 2-aMino-5-Methyl-3-Pyridinol
  • SMILES OC1=CC(C)=CN=C1N

Description

2-Amino-5-methylpyridin-3-ol features a pyridinol scaffold with strategically positioned amino and methyl groups, enabling enhanced electron density at the ortho position. This configuration supports robust metal coordination and facilitates integration into chelating ligands or bioactive scaffolds. The compound exhibits stability under standard bench conditions and demonstrates favorable solubility in polar solvents, streamlining its use in synthetic and medicinal chemistry workflows.

Application

2-Amino-5-methylpyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles through standard coupling and functionalization reactions. Its ortho-diolamine motif supports robust metal coordination and facilitates transition-metal-catalyzed transformations. The molecule exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   59.14
  • LogP   0.67782
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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