1-Bromo-4,5-difluoro-2-methoxybenzene

Name: 1-Bromo-4,5-difluoro-2-methoxybenzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 202865-58-5
Cat. No. CS-W010460
Purity≥98%
MDL No.MFCD00070753

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Bromo-4,5-difluoro-2-methoxybenzene|CS-W010460

Structure of 202865-58-5

Size

Price

Quantity

* Please select Quantity before adding items.

Description

1-Bromo-4,5-difluoro-2-methoxybenzene features a trifunctional aromatic core with orthogonal reactivity. The bromo group enables palladium-catalyzed cross-coupling, while the fluorine atoms offer enhanced metabolic stability and electron-withdrawing effects. The methoxy substituent provides steric and electronic modulation, improving solubility and directing electrophilic substitution. This compound serves as a key building block in the synthesis of bioactive molecules and functional materials.

Application

1-Bromo-4,5-difluoro-2-methoxybenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions with high efficiency. The ortho-fluorine atoms facilitate directed ortho-metalation, while the methoxy group provides moderate electron donation and enhanced solubility. Bench-stable and compatible with standard reaction conditions, it offers predictable reactivity in Suzuki, Stille, and Negishi couplings, making it ideal for constructing complex aromatic scaffolds.

General Information

CAS No. 202865-58-5
Cat. No. CS-W010460
Purity ≥98%
MDL No. MFCD00070753
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅BrF₂O
Molecular Weight 223.02
Synonym(s) 2-Bromo-4,5-difluoroanisole
SMILES COC1=CC(F)=C(F)C=C1Br

Computational Chemistry Data

TPSA 9.23
LogP 2.7359
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P301+P310-P330-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

1-Bromo-4,5-difluoro-2-methoxybenzene sigma1-Bromo-4,5-difluoro-2-methoxybenzene manufacturer1-Bromo-4,5-difluoro-2-methoxybenzene price1-Bromo-4,5-difluoro-2-methoxybenzene structure1-Bromo-4,5-difluoro-2-methoxybenzene SDSbuy 1-Bromo-4,5-difluoro-2-methoxybenzene1-Bromo-4,5-difluoro-2-methoxybenzene supplier1-Bromo-4,5-difluoro-2-methoxybenzene uses1-Bromo-4,5-difluoro-2-methoxybenzene molecular weightprice of 1-Bromo-4,5-difluoro-2-methoxybenzene1-Bromo-4,5-difluoro-2-methoxybenzene chemical name formula of 1-Bromo-4,5-difluoro-2-methoxybenzene

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

1-Bromo-4,5-difluoro-2-methoxybenzene

CAS No. 202865-58-5

Recommended Products